Condition: Acute Myeloid Leukemia, Adult · Cardiotoxicity · Endothelial Dysfunction · Sponsor: Samara State Medical University
Acute myeloid leukemia (AML) is a clonal neoplastic disease of the hematopoietic tissue associated with a mutation in the precursor cell of hematopoiesis, which results in a differentiation block and uncontrolled proliferation of immature myeloid cells. Anthracycline antibiotics have been an integral part of the treatment of acute myeloid leukemia since the 1970s. However, the clinical usefulness of anthracyclines is limited primarily by the high incidence of cardiotoxicity. According to the European Society of Cardiology guidelines for cardio-oncology, cardiovascular toxicity is defined as any impairment of cardiac function associated with anticancer treatment, as the term encompasses both a wide range of possible clinical manifestations and an etiological relationship with various treatments, including chemotherapy, radiation therapy, immunotherapy and treatment with targeted drugs. Cardiovascular toxicity can be acute, subacute or delayed, manifesting many years after chemotherapy or radiation therapy, involving a number of cardiac structures, which can lead to the development of heart failure, coronary heart disease, valvular heart disease, arrhythmias, including cardiac conduction disorders and diseases of the pericardium. Anthracycline-induced cardiotoxicity is the negative effect of anthracyclines on normal cardiac activity due to their toxic effects on the heart muscle and the cardiac conduction system. Anthracycline-induced cardiotoxicity manifests as asymptomatic …
This description comes directly from the study's public registry record.
Igor Davydkin, Doctor of Medical Sciences · 89270145544 · i.l.davydkin@samsmu.ru
Angelika Antipova · 89228862745 · a.v.antipova@samsmu.ru
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| Clinics of the Samara Medical University | Samara, Samara Oblast, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05703126