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Study identifier: NCT05701969 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift

Condition: Sleep Disorders, Circadian Rhythm  ·  Sponsor: University of Virginia

PhaseEARLY_Phase 1
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

Anesthesiology residency requires extended and overnight shifts, which may negatively impact the quantity and quality of sleep. Previous studies have investigated the effect of night float shift work on anesthesiology resident sleep and performance and demonstrated that total sleep quantity and time spent in deep and rapid eye movement (REM) sleep were significantly reduced during night float and did not return to baseline after 3 nights of recovery. Melatonin is a hormone produced by the pineal gland, which regulates the circadian rhythm that governs sleep. Exogenous melatonin may be used as a sleep aid and is available over the counter in the United States. Melatonin is effective in realigning the circadian rhythm disorder caused by night shift work and increasing sleep duration; however, melatonin's effect on improving sleep in resident trainees has not been investigated. The investigators propose a prospective double-blinded randomized control trial to investigate the effect of melatonin on sleep quantity and quality in resident physicians assigned to a night float system.

This description comes directly from the study's public registry record.

Talk to the study team

Keita Ikeda, PH.D.  ·  9195931174  ·  ki2d@uvahealth.org

Emily Chuang, MA  ·  7575348912  ·  QGZ2TK@uvahealth.org

Always discuss trial participation with your own doctor first.

Locations (1)

University of VirginiaCharlottesville, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05701969