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Study identifier: NCT05701917 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

Condition: Venous Thromboembolism · Deep Venous Thrombosis · Post-Thrombotic Syndrome  ·  Sponsor: Inari Medical

PhaseNA
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.

This description comes directly from the study's public registry record.

Talk to the study team

Kevin Wilhelmi  ·  602-578-0738  ·  kevin.wilhelmi@stryker.com

Sara Willis  ·  sara.willis@stryker.com

Always discuss trial participation with your own doctor first.

Locations (64)

Honor HealthScottsdale, Arizona, United StatesRecruiting
Pima Heart and VascularTucson, Arizona, United StatesRecruiting
UCI Medical CenterOrange, California, United StatesRecruiting
Vascular and Interventional Specialists of Orange CountyOrange, California, United StatesRecruiting
Huntington HealthPasadena, California, United StatesRecruiting
University Of ColoradoDenver, Colorado, United StatesRecruiting
Yale UniversityNew Haven, Connecticut, United StatesRecruiting
MedStar Health Research InstitutionWashington D.C., District of Columbia, United StatesRecruiting
Manatee Memorial HospitalBradenton, Florida, United StatesTerminated
Baptist Health Research InstituteJacksonville, Florida, United StatesRecruiting
Lakeland Vascular InstituteLakeland, Florida, United StatesTerminated
HCA Florida Largo HospitalLargo, Florida, United StatesTerminated

+ 52 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05701917