Condition: Metastatic Castration-resistant Prostate Cancer · Recurrent Epithelial Ovarian Cancer · Breast Cancer · Sponsor: Valerio Therapeutics
This is a phase 1b/2 open-label, multicenter, basket study to determine the safety, anti-tumor activity, tolerability, and pharmacokinetics /pharmacodynamics of AsiDNA in combination with olaparib in participants with recurrent epithelial ovarian cancer, breast cancer and metastatic castration-resistant prostate cancer who have progressed on previous Poly (ADP-ribose) polymerase (PARP) inhibitor therapy. The study will be conducted in two phases. The Phase 1b dose escalation study designed to establish the safety, tolerability, pharmacologically active doses/ maximum tolerated dose and/or recommended phase 2 dose of AsiDNA in combination with olaparib.
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| Next Oncology | San Antonio, Texas, United States | — |
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Source record: clinicaltrials.gov/study/NCT05700669