Condition: Recurrent High Grade Glioma · Anaplastic Astrocytoma · Anaplastic Oligodendroglioma · Sponsor: University of Nebraska
Glioblastoma (GBM), WHO grade IV glioma, represents the majority of adult malignant primary brain tumors, with an incidence of 2-3 per 100,000 person-years. The survival for GBM has increased in the last decade but is still low with a median survival of 15-18 months. Recurrence after initial standard therapy, radiation therapy and chemotherapy with temozolomide, few options are available. Even with further therapy, median progression free survival at 6 months after first relapse (PFS-6) is only 15%. Similarly, anaplastic astrocytoma and anaplastic oligodendroglioma, grade III gliomas, once recurrent after radiation therapy and first-line chemotherapy, have identical therapeutic options and poor outcomes with PFS-6 of 31%. Temozolomide (TMZ) has a favorable side effect profile and is available orally, however, cytotoxicity occurs. Metronomic temozolomide at low doses on a continuous schedule, have demonstrated better survival in studies. This study will determine the recommended dose and the side effects of PCI-24781/Abexinostat with metronomic temozolomide.
This description comes directly from the study's public registry record.
Michaela K Savine, RN · 402-836-9488 · misavine@unmc.edu
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| University of Nebraska Medical Center | Omaha, Nebraska, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05698524