Condition: Nonalcoholic Fatty Liver Disease · Type 2 Diabetes Mellitus · Sponsor: King Saud University
The global rise in the prevalence of obesity paved the way for the increased prevalence of yet another obesity-related complication significant enough to be considered within the roster of major public health threats: non-alcoholic fatty liver disease (NAFLD). In this follow-up study, the investigators will attempt to decipher the natural history of hepatic steatosis among patients with type 2 diabetes mellitus (T2DM) using state-of-the-art methods in a well-characterized Saudi cohort. The investigators aim also to validate existing biomarkers of disease severity and explore the pathogenesis of progressive disease using metabolic profiling technologies. A total of 1000 adult Saudi patients (males and females) with T2DM will be recruited. Those with co-morbidities, including hepatic decompensation, will be excluded. Participants will be followed three times for a total of 10 years/patient (Year 2, Year 5, and Year 10), and measures such as dietary evaluations, anthropometrics, and urine, stool, and blood examinations will be performed. Patients who develop NAFLD will be noted, and patterns/changes in the metabolic profile will be examined. For this specific grant (the first 2 years of the whole project), the investigators will be able to recruit the study cohort, do the baseline anthropometric, imaging, and biochemical measurements, and report the prevalence of NAFLD among patients with T2DM. This information will be the basis of subsequent follow-up and allow for validating p…
This description comes directly from the study's public registry record.
Assim A Alfadda, MD · 0557021171 · aalfadda@ksu.edu.sa
Rukhsana Gul, MD · 0501387295 · Rgul@ksu.edu.sa
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| King Fahad Medical City | Riyadh, Select A State Or Province, Saudi Arabia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05697991