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Study identifier: NCT05690048 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)

Condition: Immunotherapy · HCC - Hepatocellular Carcinoma  ·  Sponsor: Michael Dill

PhasePhase 2
Planned participants48
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The interventional, randomized, placebo-controlled, double-blind phase II-trial FLORA will assess safety and immunogenicity of fecal microbiota transfer in combination with standard of care immunotherapy in advanced hepatocellular carcinoma (HCC) in a parallel group design. Subjects will be randomized 2:1 into either the FMT or placebo group.

This description comes directly from the study's public registry record.

Talk to the study team

Michael T Dill, PhD  ·  06221 568611  ·  michael.dill@med.uni-heidelberg.de

Conrad Rauber, MD/PhD  ·  06221568611  ·  conrad.rauber@med.uni-heidelberg.de

Always discuss trial participation with your own doctor first.

Locations (7)

University Hospital HeidelbergHeidelberg, Baden-Wurttemberg, GermanyRecruiting
University Hospital AugsburgAugsburg, GermanyNot Yet Recruiting
University Hospital EssenEssen, GermanyNot Yet Recruiting
University Hospital MannheimMannheim, GermanyNot Yet Recruiting
University Hospital RegensburgRegensburg, GermanyNot Yet Recruiting
University Hospital TübingenTübingen, GermanyNot Yet Recruiting
University Hospital UlmUlm, GermanyNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05690048