← Eichor
Study identifier: NCT05688904 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy

Condition: Imipramine · Photodynamic Therapy · Actinic Keratosis  ·  Sponsor: Wright State University

PhasePhase 1
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.

This description comes directly from the study's public registry record.

Talk to the study team

Manager, Clinical Research Operations  ·  937-245-7500  ·  pturesearch@wrightstatephysicians.org

Regulatory Specialist  ·  937-245-7500  ·  pturesearch@wrightstatephysicians.org

Always discuss trial participation with your own doctor first.

Locations (1)

Wright State PhysiciansFairborn, Ohio, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05688904