Condition: Schwannomatosis · Schwannomas · Pain, Chronic · Sponsor: Massachusetts General Hospital
This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with moderate-to-severe pain due to schwannomatosis (SWN). This Master Study is being conducted as a platform that may allow participants with pain associated with schwannomatosis to receive a novel intervention throughout this study. Embedded within the Master Study are individual drug sub-studies: * Investigational Drug Sub-Study A: Siltuximab * Investigation Drug Sub-Study B: Erenumab-Aooe
This description comes directly from the study's public registry record.
Scott Plotkin, MD, PhD · 617-643-8992 · lmhibyan@partners.org
Lei Xu, PhD · 617-726-8051 · lei@steele.mgh.harvard.edu
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| Massachusetts General Hospital Cancer Center | Boston, Massachusetts, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05684692