Condition: Coronary Artery Disease · Sponsor: University of Florida
Two strategies have both proven to be effective in reducing bleeding complications while preserving efficacy compared with maintaining long-term DAPT with aspirin and a potent P2Y12 inhibitor: a) DAPT de-escalation (i.e., switching from prasugrel or ticagrelor to clopidogrel while maintaining aspirin) and b) potent P2Y12 inhibitor monotherapy (i.e., maintaining prasugrel or ticagrelor and dropping aspirin). These strategies have been tested in a number of trials and have led to changes in practice guidelines to consider either one of these strategies as bleeding reduction approaches among ACS patients undergoing PCI. However, comparative assessments between DAPT de-escalation and potent P2Y12 inhibitor monotherapy are lacking.
This description comes directly from the study's public registry record.
Dominick J Angiolillo, MD,PhD · +1-904-244-3378 · dominick.angiolillo@jax.ufl.edu
Andrea Burton, MPH, CCRP · +1-904-244-5617 · Andrea.Burton@jax.ufl.edu
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| University of Florida | Jacksonville, Florida, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05681702