Condition: HER2 Positive Advanced Solid Tumors · Sponsor: Chinese PLA General Hospital
Chimeric antigen receptor modified T (CAR-T) cell therapy still has multiple difficulties in solid tumors, such as absence of tumor specific antigens, complex immunosuppressive tumor microenvironment, and tumor heterogeneity. In this study, investigators developed a novel hypoxia-stimulated CAR expression system (HypoSti.CAR) that could enable CAR-T cell effectively expand and survive in hypoxic tumor microenvironment. After accomplishment of animal model verification, investigators conduct this clinical trial in order to assess the in vivo safety, feasibility and efficacy of HypoSti.CAR-HER2 T cells in HER2 antigen positive advanced solid tumors.
This description comes directly from the study's public registry record.
Kaichao Feng, MD · +861066947300 · timothyfkc@126.com
Weidong Han, PhD · +861066937463 · hanwdrsw69@yahoo.com
Always discuss trial participation with your own doctor first.
| Kaichao Feng | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05681650