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Study identifier: NCT05681195 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

Condition: Primary Central Nervous System Lymphoma · Secondary Central Nervous System Lymphoma · Relapsed Cancer  ·  Sponsor: Baptist Health South Florida

PhasePhase 2
Planned participants15
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being conducted to evaluate the safety and efficacy of the combination of pemetrexed and zanubrutinib (called induction therapy) followed by zanubrutinib treatment alone (also called maintenance therapy) in people who have relapsed or refractory (RR) primary central nervous system lymphoma (PCNSL) or isolated central nervous system relapse of B cell lymphoma (SCNSL). Assessments include how well people respond to this treatment, whether their disease gets better or worse, and their survival. Safety of this treatment and its side effects also will be assessed.

This description comes directly from the study's public registry record.

Talk to the study team

Yuliya Linhares, M.D.  ·  (786) 596-2000  ·  YuliyaL@baptisthealth.net

Allison Miller  ·  (786) 527-8519  ·  Allison.Miller@baptisthealth.net

Always discuss trial participation with your own doctor first.

Locations (1)

Miami Cancer Institute at Baptist Health, Inc.Miami, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05681195