Condition: Liver Transplantation · Sponsor: University Medical Center Groningen
End-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary complications, when compared with static cold storage. End-ischemic DHOPE can be used to prolong donor liver preservation time for up to 24 hours. According to IDEAL-D (Idea, Development, Exploration, Assessment, Long term study-Framework for Devices), scientific evidence for prolonged DHOPE has currently reached stage 3. Assessment of long-term outcomes after prolonged DHOPE preservation based on real-world data (i.e., IDEAL-D stage 4) is currently still lacking.
This description comes directly from the study's public registry record.
Vincent E de Meijer, MD, PhD · +31503616161 · v.e.de.meijer@umcg.nl
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| University Medical Center Groningen | Groningen, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05680246