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Study identifier: NCT05673499 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery

Condition: Congenital Disorders · Cerebral Desaturation · Neonatal Surgery  ·  Sponsor: Children's Hospital of Philadelphia

PhaseN/A
Planned participants900
Who can joinAll sexes, N/A to 60 Weeks
Healthy volunteersNo

About this study

The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1. The perioperative factors associated with occurrence of cerebral desaturation 2. The association between perioperative cerebral desaturation, perioperative/hospital outcomes, and physiological conditions. Participants will undergo Near-infrared spectroscopy (NIRS) and electroencephalogram (EEG) monitoring for one hour before surgery, during surgery, and up to 24 hours after surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Paula Hu, RN, MSPH  ·  267-426-2961  ·  hup@chop.edu

Elizabeth Ramsay  ·  267-270-5087  ·  ramsaye2@chop.edu

Always discuss trial participation with your own doctor first.

Locations (15)

Children's Hospital at Montefiore/Albert Einstein College of MedicineNew York, New York, United StatesNot Yet Recruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
Children's Medical Center DallasDallas, Texas, United StatesNot Yet Recruiting
Children's Memorial Hermann HospitalHouston, Texas, United StatesNot Yet Recruiting
Perth Children's HospitalNedlands, AustraliaRecruiting
Royal Children's HospitalParkville, AustraliaNot Yet Recruiting
Hospital das Clínicas, Faculdade de Medicina, Universidade de São PauloSão Paulo, BrazilRecruiting
Guangzhou women and children's medical centerGuangzhou, ChinaNot Yet Recruiting
Shanghai Children's Medical CenterShanghai, ChinaNot Yet Recruiting
Shengjing Hospital of China Medical UniversityShenyang, ChinaNot Yet Recruiting
West China Hospital and West China Second University HospitalSichuan, ChinaNot Yet Recruiting
Centre Hospitalier Universitaire de Bordeaux, Hopital des enfantsBordeaux, FranceNot Yet Recruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05673499