Condition: Acute Myeloid Leukemia · Recurrent Adult Acute Myeloid Leukemia · Refractory Acute Myeloid Leukemia · Sponsor: City of Hope Medical Center
This phase I trial tests the safety, side effects, and the best dose of anti-CD33 chimeric antigen receptor (CAR) T-Cell therapy in treating patients with acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). CAR T-cell therapy is a type of treatment in which a patient or donor's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient's or donor's blood. Then the gene for a special receptor that binds to a certain protein on the patient's cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor. Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion for treatment of certain cancers.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| City of Hope Medical Center | Duarte, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05672147