Condition: Medulloblastoma · Central Nervous System Tumor, Pediatric · Ependymoma · Sponsor: Beijing Tiantan Hospital
Primary malignant central nervous system (CNS) tumors are the second most common childhood malignancies. Amongst, medulloblastomas are the most common malignant brain tumor of childhood and occur primarily in the cerebellum. According to molecular characteristics, medulloblastomas were classified into four subtypes: WNT, SHH, Group3 and Group4 and different prognosis were noticed between subgroups. Several genetic predispositions related to clinical outcome were also discovered and might influence the treatment of medulloblastomas as novel pharmaceutical targets. This study aims to investigate genetic and cellular profiles of pediatric brain malignancies, mostly medulloblastomas, and other central nervous system tumor based on WGS, RNA-seq, single-cell sequencing and spatial transcriptomics. We also aim to investigate the correlation between genetic characteristics and clinical prognosis.
This description comes directly from the study's public registry record.
Tao Jiang, MD · +8613501306106 · doctorjiangtt@163.com
Yahui Zhao, MD · +8618519325917 · yahuii.zhao@hotmail.com
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| Beijing Tiantan Hosiptal | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05672043