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Study identifier: NCT05669833 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients

Condition: Psoriatic Arthritis  ·  Sponsor: University of Pennsylvania

PhasePhase 3
Planned participants63
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The trial is an open-label randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab) among patients with PsA who have an inadequate response to a TNFi.

This description comes directly from the study's public registry record.

Talk to the study team

Sarah Gillespie  ·  (215) 614-1840  ·  sarah.hopkins@pennmedicine.upenn.edu

Study Coordinator  ·  SpAProgram@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (14)

Family Arthritis CenterLoxahatchee Groves, Florida, United StatesRecruiting
Healing RheumatologyPlant City, Florida, United StatesRecruiting
Southwest Florida RheumatologyRiverview, Florida, United StatesRecruiting
Parris and AssociatesLilburn, Georgia, United StatesRecruiting
University of Massachusetts Chan Medical SchoolWorcester, Massachusetts, United StatesRecruiting
University of Nebraska Medical CenterOmaha, Nebraska, United StatesRecruiting
New York UniversityNew York, New York, United StatesRecruiting
Cincy ArthritisBlue Ash, Ohio, United StatesRecruiting
Southern Ohio RheumatologyWheelersburg, Ohio, United StatesRecruiting
Hospital at the University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting
Cumberland RheumatologyCrossville, Tennessee, United StatesRecruiting
Heritage Rheumatology and Arthritis CareColleyville, Texas, United StatesRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05669833