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Study identifier: NCT05668962 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

Condition: Thyroid Cancer · Thyroid Carcinoma · Metastatic Thyroid Cancer  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants30
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-refractory thyroid cancer. This research study involves the study drug selpercatinib in combination with standard of care treatments, I-131 and thyrotropin alfa (rhTSH).

This description comes directly from the study's public registry record.

Talk to the study team

Lori J. Wirth, MD  ·  617-724-1134  ·  lwirth@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (6)

MedStar Washington Hospital CenterWashington D.C., District of Columbia, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
University of MichiganAnn Arbor, Michigan, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05668962