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Study identifier: NCT05665491 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Role of Parent Interpretation Bias in the Transmission of Anxiety to Children

Condition: Anxiety  ·  Sponsor: Mclean Hospital

PhaseNA
Planned participants300
Who can joinAll sexes, 7 Years to no upper limit
Healthy volunteersNo

About this study

Approximately 30% of children will experience an anxiety disorder, making anxiety the most common mental health problem among children in the United States. However, few children receive treatment and even our most effective anxiety treatments leave up to half of children in need of additional intervention. Despite the well-established role of parent anxiety in transmitting and maintaining child anxiety, the lack of data on specific parent mechanisms underlying the intergenerational transmission of anxiety is a critical barrier to informing novel targets of personalized treatments. Consistent with NIMH's Strategic Plan, Objective 2.2 to understand risk factors and behavioral indicators of mental illness across the lifespan and to identify novel intervention targets based on knowledge of psychological mechanisms, the current study focuses on interpretation bias, the tendency to perceive threat in ambiguous situations. The overall objective of this project is to empirically test a theoretical model of the intergenerational transmission of anxiety focused on parent interpretation bias as a root cause. Our specific aims are to test theorized effects of parent interpretation bias on (1) parent behavior and (2) child interpretation bias and (3) evaluate potential moderators to refine theories of intergenerational transmission of anxiety and inform future personalized interventions. Our central hypothesis is that parent interpretation bias influences child interpretation bias throug…

This description comes directly from the study's public registry record.

Talk to the study team

Courtney Beard, PhD  ·  617-855-3557  ·  cbeard@mclean.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

McLean HospitalBelmont, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05665491