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Study identifier: NCT05664516 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder

Condition: Binge-eating Disorder  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants60
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

This study evaluates the impact of intranasal oxytocin vs placebo in patients with binge eating disorder or episodes of binging. We hypothesize that 8 weeks of intranasal oxytocin vs placebo will improve clinical outcomes \[reduction in bingeing frequency\], and have a satisfactory safety and tolerability profile. We will also explore the predictive value of changes in homeostatic appetite, reward sensitivity, and impulse control, the identified underlying mediators, as assessed 4 weeks into the intervention, for treatment success after 8 weeks of the intervention.

This description comes directly from the study's public registry record.

Talk to the study team

Lauren Shabazian, NP  ·  617-726-0047  ·  lshabazian@mgh.harvard.edu

Jordan Hillard  ·  617-726-0047  ·  jhillard1@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Neuroendocrine Unit Research CenterBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05664516