Condition: Systemic Inflammatory Response Syndrome · Sponsor: Assistance Publique - Hôpitaux de Paris
BACKGROUND Controlling vascular leakage, which is independently associated with mortality during Sepsis and cardiogenic shock, may be a promising approach during systemic inflammatory response syndrome (SIRS). During a collaborative work between La Pitié-Salpêtrière intensive care unit (ICU) and the unit INSERM U1050 (National Institute oh Health and medical Research), we identified 38 genes associated with capillary leakage during systemic inflammation response syndrome (SIRS) in humans. The aim of this study is to evaluate their possible implication in vascular hyperpermeability associated with METHODS SIRS-PERM is a prospective multicenter cohort study, testing the correlation between the plasma and broncho-alveolar levels of proteins isolated from our first screening, and the level of vascular leakage during SIRS. All patients admitted in the European Georges-Pompidou or La Pitié-Salpêtrière ICU and presenting a SIRS will be eligible for inclusion. Plasma samples will be collected at day 0, D1, D3 and D7, as well as broncho-alveolar lavage samples if clinically indicated. Concentration of each protein will be determined by ELISA in those samples. A statistical association will be then tested between each protein concentration and, for each time-point, the level of capillary leakage (daily weight and fluid balance, extra-vascular lung water index and pulmonary permeability index measured by transpulmonary thermodilution), and ARDS (acute respiratory distress syndrome) sev…
This description comes directly from the study's public registry record.
Nicolas Brechot, MD,PhD · 1-56-09-23-42 · nicolas.brechot@aphp.fr
Emmanuelle Guérin, MD · 1-56-09-32-04 · emmanuelle.guerin@aphp.fr
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| Adult Medical-Surgical Intensive Care Unit, Necker Hospital of the Sick Children | Paris, France | Recruiting |
| Medical Intensive Care Unit, Georges Pompidou European Hospital | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05663216