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Study identifier: NCT05663034 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Condition: Traumatic Brain Injury · Insomnia · Depression  ·  Sponsor: Johns Hopkins University

PhaseNA
Planned participants360
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia symptoms and ameliorating depressive symptoms in persons with mild to moderate TBI and comorbid Post-Traumatic Stress Symptoms (PTSS) and insomnia symptoms in a 360 patients. Participants will undergo assessment (psychosocial questionnaires, neurocognitive testing, sleep monitoring) at baseline, at the end of treatment, and at 2-, 6- and 12-weeks post-treatment. The primary outcome is sleep as measured by the Insomnia Severity Index (ISI).

This description comes directly from the study's public registry record.

Talk to the study team

Luis Buenaver, PHD  ·  4105507986  ·  lbuenav1@jhmi.edu

Elizabeth Wysocki, MS  ·  ewysock2@jhu.edu

Always discuss trial participation with your own doctor first.

Locations (5)

Intrepid Spirit Center - Eglin Air Force BaseEglin Air Force Base, Florida, United StatesRecruiting
Naval School Explosive Ordance Disposal - Eglin Air Force BaseEglin Air Force Base, Florida, United StatesRecruiting
Walter Reed National Medical Military CenterBethesda, Maryland, United StatesRecruiting
Womack Army Medical CenterFort Bragg, North Carolina, United StatesRecruiting
Madigan Army Medical CenterFort Lewis, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05663034