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Study identifier: NCT05661903 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

Condition: Chronic Pain  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants180
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for two week intervals up to six weeks after enrollment, and on the final day of study participation, for one hour intervals, in a multi-crossover design. In a subset of patients we will also perform combined positron emission tomography/magnetic resonance imaging at baseline, week 2 and week 4.

This description comes directly from the study's public registry record.

Talk to the study team

Brian Wainger, MD PhD  ·  617-726-8810  ·  BWAINGER@PARTNERS.ORG

Always discuss trial participation with your own doctor first.

Locations (3)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05661903