Condition: Precursor Cell Lymphoblastic Leukemia-Lymphoma · Sponsor: Institute of Hematology & Blood Diseases Hospital, China
The pediatric-inspired regimen has greatly improved the prognosis of adult patients with with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL), but relapse remains a great challenge. Venetoclax (Ven) is an oral, selective inhibitor of B-cell lymphoma 2 (Bcl-2). Although this drug is currently used primarily for acute myeloid leukemia, in vitro as well as small cohort studies suggest a effect in acute lymphoblastic leukemia. This study proposes to combine pediatric-inspired regimen with venetoclax for the treatment of adult patients with Ph- ALL, aiming to improve the MRD-negative complete remission rate measured by flow cytometry after induction and to reduce relapse, thus further improving patients overall survival.
This description comes directly from the study's public registry record.
Jianxiang Wang, Dr · 86-22-23909120 · wangjx@ihcams.ac.cn
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| Institute of Hematology & Blood Diseases Hospital | Tianjin, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05660473