Condition: Colorectal Neoplasms · Sponsor: Maastricht University Medical Center
Irinotecan-based systemic therapy is a treatment option for metastatic or unresectable colorectal cancer. However, this therapy has two major disadvantages, namely, an unpredictable response to the treatment and severe side effects, for instance diarrhea or a low white blood cell count (neutropenia). Therefore, the OPTIMA study was developed to find out if biomarkers, such as the molecular profile of the tumor, the UGT1A1 genotype and activity of the bacterial enzyme β-glucuronidase, can predict response and side effects during irinotecan treatment. By looking at these biomarkers, treatments could be more personalized, resulting into enhanced therapy efficiency, increased optimal survival and a better quality of life.
This description comes directly from the study's public registry record.
Janine Ziemons, M.Sc. · +31 (0)433881558 · j.ziemons@maastrichtuniversity.nl
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| Maastricht UMC+ | Maastricht, Limburg, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05655780