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Study identifier: NCT05655312 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

Condition: Recurrent Melanoma (Skin) · Metastatic Melanoma · Melanoma Stage IV  ·  Sponsor: Perspective Therapeutics

PhasePhase 1/Phase 2
Planned participants300
Who can joinAll sexes, 18 Years to 90 Years
Healthy volunteersNo

About this study

In this first-in human, phase I/IIa study, the safety and efficacy of \[212Pb\]VMT01, an alpha-particle emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with nivolumab in subjects with unresectable and metastatic melanoma.

This description comes directly from the study's public registry record.

Talk to the study team

ClinicalTrials at Perspectivetherapeutics  ·  206-676-0900  ·  clinicaltrials@perspectivetherapeutics.com

Always discuss trial participation with your own doctor first.

Locations (13)

University of California IrvineOrange, California, United StatesRecruiting
Mayo ClinicJacksonville, Florida, United StatesRecruiting
University of MiamiMiami, Florida, United StatesRecruiting
Sarasota Memorial HospitalSarasota, Florida, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
University of KentuckyLexington, Kentucky, United StatesRecruiting
Mayo Clinic RochesterRochester, Minnesota, United StatesRecruiting
Saint Louis University HospitalSt Louis, Missouri, United StatesRecruiting
Washington University of St. LouisSt Louis, Missouri, United StatesRecruiting
Nebraska Cancer SpecialistsOmaha, Nebraska, United StatesRecruiting
Fox Chase Cancer CenterPhiladelphia, Pennsylvania, United StatesRecruiting
UPMC Hillman Cancer CenterPittsburgh, Pennsylvania, United StatesRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05655312