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Study identifier: NCT05653778 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Scrambler Therapy for Corticobasal Syndrome-Associated Pain

Condition: Corticobasal Degeneration · Corticobasal Syndrome · Pain, Neuropathic  ·  Sponsor: Johns Hopkins University

PhaseNA
Planned participants25
Who can joinAll sexes, 50 Years to 89 Years
Healthy volunteersNo

About this study

The goal of this pilot trial is to test whether scrambler therapy (ST) is an effective treatment for neuropathic pain in patients with corticobasal syndrome (CBS). The main question it aims to answer is: Will ST reduce pain scores by at least 33% at one month in this pilot trial, justifying further multi-center trials? Participants will: * be randomly assigned treatment from either transcutaneous electrical nerve stimulation (TENS) or ST for pain initially (eventually all patients will receive ST). * have superficial electrocardiogram (ECG) electrodes placed on the dermatomes involved with pain * obtain treatment lasting 30-40 minutes or until pain relief is obtained Researchers will compare patient's response to pain relief with TENS and ST to determine if ST is an effective treatment for central neuropathic pain.

This description comes directly from the study's public registry record.

Talk to the study team

Alexander Pantelyat, MD  ·  410-502-3290  ·  apantel1@jhmi.edu

Maria Schmidt, CRNP  ·  410-502-0133  ·  mschmi61@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Johns Hopkins School of MedicineBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05653778