Condition: Glioblastoma Multiforme, Adult · Sponsor: Centre Paul Strauss
Glioblastoma (GBM) is the most common primary brain cancer in adults. Surgery, chemoradiotherapy (temozolomide TMZ) and then adjuvant TMZ is the standard treatment. But, most patients relapse in a median time of 8-9 months; the median overall survival (OS) ranged from 15 to 18 months. Some frail patients received hypofractionated radiation and concomitant and adjuvant TMZ. For some, the radiation dose is not optimal. Moreover, recurrences develop mainly in the initial tumor site. These two reasons justify increasing the dose. To limit the movements of these fragile patients, the method consists of increasing the dose without increasing the number of sessions by using the Simultaneous Integrated Boost (SIB) which increases the dose in targeted volumes while the rest of the volume receives a minimum dose. A phase I trial showed the possibility of increasing the dose in SIB up to 80 Gy in a part of the GBM enhanced on MRI. FDOPA PET detects certain more aggressive tumor areas, areas likely to recur. Integrating them into the SIB seems appropriate. A phase II trial showed the interest of SIB guided by FDOPA PET in terms of progression-free survival but without impact on OS. This study differed from the one the investigators propose, because a dose and conventional fractionation, identical to that of the European Organization for Research and Treatment of Cancer/National Cancer Information Center (NCIC/EORTC) protocol were delivered, the gliomas were unmethylated MGMT, less like…
This description comes directly from the study's public registry record.
Anne ANTHONY · +33(0)388252413 · promotion-rc@institut-strauss.fr
MANON VOEGELIN · +33(0)3 68 33 95 23 · promotion-rc@institut-strauss.fr
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| CHRU de Nancy | Nancy, De, France | Recruiting |
| Centre Paul Strauss | Strasbourg, France | Recruiting |
| ICL | Vandœuvre-lès-Nancy, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05653622