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Study identifier: NCT05652686 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

Condition: Small Cell Lung Cancer (SCLC) · Large Cell Neuroendocrine Cancer (LCNEC) · Neuroendocrine Prostate Cancer (NEPC)  ·  Sponsor: Phanes Therapeutics

PhasePhase 1/Phase 2
Planned participants203
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a first-in-human, Phase 1/2, open-label, dose escalation, dose expansion and combination study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Peluntamig (PT217) as a monotherapy and in combination with chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Phanes Therapeutics  ·  858-766-0852  ·  clinical-trials@phanestx.com

Always discuss trial participation with your own doctor first.

Locations (15)

City of Hope (City of Hope National Medical Center, City of Hope Medical Center)Duarte, California, United StatesRecruiting
USC Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
Sarah Cannon Research Institute at HealthONEDenver, Colorado, United StatesRecruiting
Yale University Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Sidney Kimmel Comprehensive Cancer Center at John HopkinsBaltimore, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Washington University School of Medicine (Siteman Cancer Center)St Louis, Missouri, United StatesRecruiting
University of North Carolina at Chapel HillChapel Hill, North Carolina, United StatesRecruiting
Duke University Medical CenterDurham, North Carolina, United StatesRecruiting
Sarah Cannon Research Institute University of OklahomaOklahoma City, Oklahoma, United StatesRecruiting
Providence Portland Medical CenterPortland, Oregon, United StatesRecruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05652686