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Study identifier: NCT05649943 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Multimodal Approach in Patients With mHSPC. Randomized Trial of APA+ADT vs APA-ADT and Local Treatment

Condition: Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)  ·  Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

PhaseNA
Planned participants566
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

Italian multicenter study, will enroll \~566 pts with oligometastatic hormone sensitive prostate cancer who are candidates to receive treatment with apalutamide. After 6 months from the start of treatment, patients will be randomized to receive local treatment based on the investigator's choice ( either one between primary radiotherapy or cytoreductive prostatectomy), in addition to apalutamide, or to continue just with medical therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Valentina Guadalupi, MD  ·  00390223903811  ·  valentina.guadalupi@istitutotumori.mi.it

Always discuss trial participation with your own doctor first.

Locations (3)

European Institute of OncologyMilan, Lombardy, ItalyNot Yet Recruiting
ASST Santi Paolo e CarloMilan, Lombardy, ItalyNot Yet Recruiting
Istituto Tumori MilanoMilan, Mi, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT05649943