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Study identifier: NCT05648448 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza

Condition: Influenza · Influenza, Human  ·  Sponsor: University of Oxford

PhasePhase 2
Planned participants3000
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

This trial will use a previously validated platform, to quantitatively assess antiviral effects in low-risk patients with high viral burdens and uncomplicated influenza, to determine in-vivo antiviral activity. In this randomised, open-label, controlled, group sequential, adaptive, platform trial, we will compare the performance of available influenza antivirals, and those with potential activity, relative to the control (no treatment) and each other. AD ASTRA study is supported by the Wellcome Trust Grant ref: 223195/Z/21/Z through the COVID-19 Therapeutics Accelerator

This description comes directly from the study's public registry record.

Talk to the study team

William Schilling, MD  ·  +662 203 6333  ·  william@tropmedres.ac

Nicholas J White, Prof  ·  +662 203 6333  ·  nickw@tropmedres.ac

Always discuss trial participation with your own doctor first.

Locations (4)

Universidade Federal de Minas GeraisMinas Gerais, BrazilRecruiting
Laos-Oxford-Mahosot Wellcome Trust Research unitVientiane, LaosRecruiting
Sukraraj Tropical & Infectious Disease HospitalKathmandu, NepalRecruiting
Faculty of Tropical Medicine, Mahidol UniversityBangkok, ThailandRecruiting

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Source record: clinicaltrials.gov/study/NCT05648448