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Study identifier: NCT05647265 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma

Condition: Pleural Biphasic Mesothelioma · Pleural Sarcomatoid Mesothelioma  ·  Sponsor: Alliance for Clinical Trials in Oncology

PhasePhase 2
Planned participants26
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial evaluates the safety and effectiveness of giving immunotherapy (nivolumab and ipilimumab) before surgery for controlling disease in patients with stage I-IIIa sarcomatoid mesothelioma. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving immunotherapy before surgery may be more effective at controlling disease in patients with sarcomatoid mesothelioma than giving immunotherapy alone.

This description comes directly from the study's public registry record.

Talk to the study team

Aaron Mansfield, MD  ·  507-293-0569  ·  mansfield.aaron@mayo.edu

Colleen Watt  ·  cwatt@bsd.uchicago.edu

Always discuss trial participation with your own doctor first.

Locations (132)

Anchorage Associates in Radiation MedicineAnchorage, Alaska, United StatesRecruiting
Anchorage Radiation Therapy CenterAnchorage, Alaska, United StatesSuspended
Alaska Breast Care and Surgery LLCAnchorage, Alaska, United StatesRecruiting
Alaska Oncology and Hematology LLCAnchorage, Alaska, United StatesRecruiting
Alaska Women's Cancer CareAnchorage, Alaska, United StatesRecruiting
Katmai Oncology GroupAnchorage, Alaska, United StatesRecruiting
Providence Alaska Medical CenterAnchorage, Alaska, United StatesRecruiting
Kingman Regional Medical CenterKingman, Arizona, United StatesRecruiting
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United StatesRecruiting
Mayo Clinic in ArizonaScottsdale, Arizona, United StatesRecruiting
PCR OncologyArroyo Grande, California, United StatesRecruiting
Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, California, United StatesRecruiting

+ 120 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05647265