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Study identifier: NCT05646316 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

Condition: Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8  ·  Sponsor: NRG Oncology

PhasePhase 3
Planned participants428
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial cancer. Standard lymph node dissection removes lymph nodes around the uterus during a hysterectomy to look for spread of cancer from the uterus to nearby lymph nodes. Sentinel lymph node mapping uses a special dye and camera to look for cancer that may have spread to nearby lymph nodes. Comparing the results of the procedures may help doctors predict the risk of long-term swelling in the legs.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (55)

George Washington University Medical CenterWashington D.C., District of Columbia, United StatesSuspended
UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at DoralDoral, Florida, United StatesRecruiting
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at KendallMiami, Florida, United StatesRecruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole MiaNorth Miami, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at PlantationPlantation, Florida, United StatesRecruiting
Augusta University Medical CenterAugusta, Georgia, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
Northwestern Medicine Cancer Center WarrenvilleWarrenville, Illinois, United StatesRecruiting
IU Health North HospitalCarmel, Indiana, United StatesRecruiting

+ 43 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05646316