Condition: Recurrent Lung Non-Small Cell Carcinoma · Stage IV Lung Cancer AJCC v8 · Sponsor: SWOG Cancer Research Network
This phase II Lung-MAP treatment trial test the combination of targeted drugs (capmatinib, osimertinib, and/or ramucirumab) in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and that has EGFR and MET gene changes. Capmatinib and osimertinib are in a class of medications called kinase inhibitors. They work by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Giving capmatinib, osimertinib, and/or ramucirumab and targeting abnormal gene changes in tumor cells may be effective in shrinking or stabilizing advanced non-small cell lung cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis | Daphne, Alabama, United States | Recruiting |
| Thomas Hospital | Fairhope, Alabama, United States | Recruiting |
| Mobile Infirmary Medical Center | Mobile, Alabama, United States | Recruiting |
| Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland | Saraland, Alabama, United States | Recruiting |
| Katmai Oncology Group | Anchorage, Alaska, United States | Recruiting |
| Kingman Regional Medical Center | Kingman, Arizona, United States | Recruiting |
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | Suspended |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | Recruiting |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | Recruiting |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | Active Not Recruiting |
| Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande, California, United States | Suspended |
| PCR Oncology | Arroyo Grande, California, United States | Recruiting |
+ 442 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05642572