Condition: Sickle Cell Disease · Acute Chest Syndrome · Sponsor: University of Chicago
The investigators are evaluating the role of a low dose of tocilizumab in treating acute chest syndrome in patients with sickle cell disease. Tocilizumab inhibits interleukin-6 (IL-6) receptors and is used to treat rheumatoid arthritis and severe cytokine release syndrome, which can be seen with chimeric antigen receptor T-cell (CAR-T) therapy, and it is also authorized for treatment of COVID-19. Since IL-6 levels are elevated in the sputum of patients with acute chest syndrome, the investigators are hopeful that this will be an effective strategy. The investigators will be looking at how a low dose of tocilizumab affects oxygen status, clinical outcomes, and laboratory markers in patients admitted to the hospital with acute chest syndrome.
This description comes directly from the study's public registry record.
Austin Wesevich, MD · 773-834-6732 · austin.wesevich@uchicagomedicine.org
Gabrielle Lapping-Carr, MD · 773-702-6808 · glappingcarr@uchicago.edu
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| University of Chicago | Chicago, Illinois, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05640271