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Study identifier: NCT05636540 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma

Condition: Pheochromocytoma · Paraganglioma  ·  Sponsor: Heather Wachtel

PhaseEARLY_Phase 1
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment. A pre-treatment 18F-FluorThanatrace (\[18F\]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic therapy. PET/CT imaging will be used to evaluate PARP-1 expression in sites of pheochromocytoma or paraganglioma using the investigational radiotracer \[18F\]FTT. This is an observational study in that \[18F\]FTT PET/CT will not be used to direct treatment decisions. While patients and referring physicians will not be blinded to the \[18F\]FTT PET/CT results, treatment decisions will be made by the treating physicians based upon clinical criteria.

This description comes directly from the study's public registry record.

Talk to the study team

Heather Wachtel, MD  ·  215-662-2341  ·  Heather.Wachtel@pennmedicine.upenn.edu

Julia T Lewandowski  ·  215-662-2961  ·  julia.lewandowski@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05636540