Condition: Coronary Artery Disease · Aortic Valve Disease · Sponsor: Rigshospitalet, Denmark
Open heart surgery, including coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) is associated with a significant risk of mortality. This study is a randomized clinical trial with the purpose of investigating four different interventions on the primary endpoint 'days alive and outside of hospital within 90 days'. The interventions are: * Dexamethasone vs. placebo administered after induction of anesthesia. * Olanzapine vs. placebo administered prior to anesthesia. * A blood-flow targeted vs. a blod-pressure targeted hemodynamic strategy while the patient is on cardio-pulmonary bypass (CPB) * Low-tidal volume ventilation vs. no ventilation of the lungs while the patient is on CPB
This description comes directly from the study's public registry record.
Sebastian Wiberg, MD, PhD · +45 35 45 17 10 · sebastian.christoph.wiberg@regionh.dk
Christian Hassager, MD, DMSc · christian.hassager@regionh.dk
Always discuss trial participation with your own doctor first.
| The Heart Centre, Rigshospitalet | Copenhagen, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05635227