Condition: Syncope, Vasovagal · Postural Orthostatic Tachycardia Syndrome · Orthostatic Intolerance · Sponsor: Simon Fraser University
The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.
This description comes directly from the study's public registry record.
Erin L Williams, BSc · 6048976372 · erin_williams_2@sfu.ca
Victoria E Claydon, PhD · 778-782-8513 · victoria_claydon@sfu.ca
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| Simon Fraser University | Burnaby, British Columbia, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05633693