Condition: Solid Tumor, Adult · Lymphoma · EphA2 Overexpression · Sponsor: Chinese PLA General Hospital
This is a pilot clinical trial for subjects with local advanced/metastatic solid tumors or relapsed/refractory (R/R) lymphomas to determine the safety, efficacy and immune response of autologous EphA2-targeting CAR-DC vaccine loaded with TP53 mutant peptide (TP53-EphA-2-CAR-DC) in combination with ICIs. It aims to: assess the safety and antitumor effects of TP53-EphA-2-CAR-DC vaccine; detect T cell response against TP53 mutant peptide and tumor neoepitopes after the treatment with TP53-EphA-2-CAR-DC vaccine and ICIs.
This description comes directly from the study's public registry record.
Weidong Han, Ph.D · 010-66937231 · hanwdrsw@sina.com
Yang Liu, M.D · 010-66939460 · liuyang301blood@163.com
Always discuss trial participation with your own doctor first.
| Biotherapeutic Department of Chinsese PLA Gereral Hospital | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05631886