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Study identifier: NCT05629702 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

Condition: Glioblastoma · Brain Tumor · Cannabis  ·  Sponsor: University of Birmingham

PhasePhase 2
Planned participants120
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersNo

About this study

ARISTOCRAT is a phase II, multi-centre, double-blind, placebo-controlled, randomised trial to compare the cannabinoid Nabiximols with placebo in patients with recurrent MGMT methylated glioblastoma (GBM) treated with temozolomide (TMZ).

This description comes directly from the study's public registry record.

Talk to the study team

Rhys Mant  ·  +441214146788  ·  aristocrat@trials.bham.ac.uk

Joshua Savage  ·  j.savage.1@bham.ac.uk

Always discuss trial participation with your own doctor first.

Locations (22)

Glan Clwyd HospitalBodelwyddan, Denbighshire, United KingdomWithdrawn
Mount Vernon Hospital, The Hillingdon Hospitals NHS Foundation TrustNorthwood, Middlesex, United KingdomRecruiting
Aberdeen Royal Infirmary, NHS GrampianAberdeen, United KingdomRecruiting
Belfast City Hospital, Belfast Health and Social Care TrustBelfast, United KingdomWithdrawn
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation TrustBirmingham, United KingdomRecruiting
Bristol Haematology & Oncology Centre, University Hospitals Bristol & Weston NHS Foundation TrustBristol, United KingdomActive Not Recruiting
Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation TrustCambridge, United KingdomRecruiting
Velindre Cancer Centre, Velindre University NHS TrustCardiff, United KingdomRecruiting
Western General Hospital, NHS LothianEdinburgh, United KingdomWithdrawn
Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & ClydeGlasgow, United KingdomWithdrawn
Castle Hill Hospital, Hull University Teaching Hospitals NHS TrustHull, United KingdomRecruiting
St James's University Hospital, Leeds Teaching Hospitals NHS TrustLeeds, United KingdomRecruiting

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05629702