Condition: Triple Negative Breast Cancer · Hormone-Resistant Breast Cancer · Non Small Cell Lung Cancer · Sponsor: A&G Pharmaceutical Inc.
This is a first in human phase 1 study of AG01 an anti-Progranulin/Glycoprotein88 (PGRN/GP88) antibody in patients with advanced solid tumors. AG01 is a recombinant monoclonal antibody expressed in a CHO production cell line. The antibody AG01 binds to human PGRN/GP88, expressed on cancer cells. This study will have a dose escalation portion (1A) to evaluate maximum tolerated dose (MTD) and/or maximum administered dose (MAD), the safety and tolerability of AG01treatment before the dose expansion portion (1B) of the study is initiated. The dose escalation portion of this study (1A) will also be used to determine the recommended phase 2 dose (RP2D) of AG01 antibody to be evaluated in the cohort expansion portion (1B).
This description comes directly from the study's public registry record.
Ginette Serrero, PhD/DSC. · (410)884-4100 · gserrero@agpharma.com
Katherine Tkaczuk, MD · (410) 328-7394 · ktkaczuk@umm.edu
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| University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05627960