Condition: Recurrent Acute Myeloid Leukemia · Refractory Acute Myeloid Leukemia · Sponsor: Thomas Jefferson University
This is a two-part phase Ib dose escalation study to evaluate the safety and preliminary efficacy of the combination of tazemetostat and CPX-351 (Part 1) and of pre-treatment with palbociclib followed by CPX-351 (Part 2) for patients with relapsed or refractory (R/R) acute myeloid leukemia (AML). Part 1 of the study will seek to establish the safety, tolerability, biological activity and recommended dose for further evaluation (RDFE) of tazemetostat in combination with standard-dose CPX-351. Part 2 of the study will seek to establish the safety, tolerability, biological activity RDFE of pre-treatment palbociclib prior CPX-351.
This description comes directly from the study's public registry record.
Gina Keiffer, MD · 215-955-2929 · gina.keiffer@jefferson.edu
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| Thomas Jefferson University Hospital | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05627232