Condition: Inherited Retinal Dystrophy Primarily Involving Sensory Retina · Sponsor: University of Washington
Aberrant retinoic acid signaling driven by the degenerating outer retina leads to pathological changes to the inner retina. The resulting hyperactivity of retinal ganglion cells leads to further diminution of the remaining vision in those afflicted with inherited retinal diseases. Inhibition of this pathway has led to improved visual function in murine models of retinal degeneration. This can be accomplished in humans with the FDA-approved irreversible inhibitor of aldehyde dehydrogenases, disulfiram.
This description comes directly from the study's public registry record.
Debarshi Mustafi, MD, PhD · 206-616-9305 · debarshi@uw.edu
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| University of Washington-South Lake Union Retina Center | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05626920