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Study identifier: NCT05625659 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

Condition: Breast Cancer  ·  Sponsor: American College of Radiology

PhaseNA
Planned participants2032
Who can joinFemale, 45 Years to 74 Years
Healthy volunteersYes

About this study

The over-arching goal of the Contrast-Enhanced Spectral Mammography Imaging Screening Trial (CMIST) is to determine if dual-energy contrast-enhanced spectral mammography (CESM) can detect more cancers with fewer false positives than digital breast tomosynthesis (DBT) in women with dense breasts. Aim 1: To evaluate the performance of CESM compared to DBT at baseline for breast-cancer screening in women with dense breasts. Aim 2: To evaluate the performance of CESM compared to DBT at the 1-year follow up for breast-cancer screening in women with dense breasts.

This description comes directly from the study's public registry record.

Talk to the study team

Christopher Comstock, MD  ·  212-746-6000  ·  chc4050@med.cornell.edu

Etta Pisano, MD

Always discuss trial participation with your own doctor first.

Locations (12)

University of Alabama, BirminghamBirmingham, Alabama, United StatesRecruiting
Boca Raton Regional Hospital - Christine E. Lynn Women's Health and Wellness InstituteBoca Raton, Florida, United StatesRecruiting
Lake Medical ImagingThe Villages, Florida, United StatesActive Not Recruiting
Boston Breast Diagnostic CenterWellesley Hills, Massachusetts, United StatesRecruiting
Henry Ford HealthDetroit, Michigan, United StatesRecruiting
Thomas Jefferson UniversitySewell, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Carolina Breast Imaging SpecialistsGreenville, North Carolina, United StatesRecruiting
Thomas Jefferson University HospitalPhiladelphia, Pennsylvania, United StatesRecruiting
The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
University of VirginiaCharlottesville, Virginia, United StatesRecruiting
St. Joseph's HospitalLondon, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05625659