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Study identifier: NCT05620719 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Multisite Advancement of Research on Chronic Posttraumatic Headache

Condition: Posttraumatic Headache  ·  Sponsor: The University of Texas Health Science Center at San Antonio

PhaseNA
Planned participants525
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

Posttraumatic headache (PTH) is a common and highly disabling consequence of traumatic brain injury (TBI) in U.S. military service members and veterans. Cognitive Behavioral Therapy for PTH has been shown to significantly improve disability outcomes in veterans with persistent PTH when delivered in-person. Telemedicine platforms can dramatically increase access to evidence-based care. However, whether CBT for PTH retains its effectiveness when delivered through a telemedicine platform has yet to be established. The purpose of this 3-arm randomized clinical trial is to compare Clinic-based Cognitive-Behavioral Therapy (CCBT) to Telemedicine-based Cognitive Behavioral Therapy (TCBT) and to treatment as usual (TAU) in 525 service members and veterans with chronic posttraumatic headaches (PTH) at 4 VA medical centers\* and 3 military treatment facilities across the U.S. Participants will be assessed for headache-related disability, headache experience, and psychiatric comorbidities across multiple time points. \*VA Palo Alto Health Care System is temporarily randomizing into TAU and TCBT only.

This description comes directly from the study's public registry record.

Talk to the study team

Nicole A Brackins, MS  ·  210-450-8076  ·  brackins@uthscsa.edu

Fermin A Carrizales  ·  210-562-6724  ·  carrizalesF@uthscsa.edu

Always discuss trial participation with your own doctor first.

Locations (8)

VA Greater Los Angeles Healthcare SystemLos Angeles, California, United StatesRecruiting
VA Palo Alto Health Care SystemPalo Alto, California, United StatesRecruiting
Tripler Army Medical Center (Desmond Doss Health Clinic, Schofield Barracks)Honolulu, Hawaii, United StatesActive Not Recruiting
Walter Reed National Military Medical CenterBethesda, Maryland, United StatesWithdrawn
Minneapolis VA Health Care SystemMinneapolis, Minnesota, United StatesRecruiting
Carl R. Darnall Army Medical Center (Fort Cavazos)Killeen, Texas, United StatesRecruiting
South Texas Veterans Health Care SystemSan Antonio, Texas, United StatesRecruiting
Brooke Army Medical CenterSan Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05620719