Condition: Depression in Adolescence · Rumination · Sponsor: Columbia University
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.
This description comes directly from the study's public registry record.
Randy P Auerbach, PhD · 646-774-5745 · rpa2009@cumc.columbia.edu
Simryn Molina, BA · simryn.molina@nyspi.columbia.edu
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| Northeastern University | Boston, Massachusetts, United States | Recruiting |
| Columbia University Irving Medical Center | New York, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05617495