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Study identifier: NCT05614739 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

Condition: Urinary Bladder Neoplasms · Neoplasm Metastasis · Ureteral Neoplasms  ·  Sponsor: Eli Lilly and Company

PhasePhase 1
Planned participants535
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435 may be used to treat cancer of the cells that line the urinary system and other solid tumor cancers that have a change in a particular gene (known as the FGFR3 gene). Participation could last up to 30 months (2.5 years) and possibly longer if the disease does not get worse.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (82)

University of Arizona - Cancer CenterTucson, Arizona, United StatesRecruiting
City of HopeDuarte, California, United StatesRecruiting
University of California, Los Angeles (UCLA) - Division of Hematology-OncologyLos Angeles, California, United StatesRecruiting
University of California - IrvineOrange, California, United StatesRecruiting
University of California (UC) Davis Comprehensive Cancer CenterSacramento, California, United StatesRecruiting
Stanford Medicine Cancer CenterStanford, California, United StatesRecruiting
Advent HealthOrlando, Florida, United StatesRecruiting
Emory University HospitalAtlanta, Georgia, United StatesRecruiting
The University of Chicago Medical Center (UCMC)Chicago, Illinois, United StatesRecruiting
Indiana University (IU) Melvin and Bren Simon Cancer CenterIndianapolis, Indiana, United StatesRecruiting
Mary Bird Perkins Cancer CenterBaton Rouge, Louisiana, United StatesRecruiting
Ochsner Clinic FoundationNew Orleans, Louisiana, United StatesRecruiting

+ 70 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05614739