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Study identifier: NCT05612594 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Adipose Dysfunction, Imaging, Physiology, and Outcomes With Sodium Glucose Cotransporter 2 Inhibitor (SGLT2i) for Sleep Apnea: The ADIPOSA Study

Condition: Sleep Apnea  ·  Sponsor: Yale University

PhasePhase 4
Planned participants164
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to test if bexagliflozin lowers the sleep apnea severity in adults who are overweight or obese with moderate to severe obstructive sleep apnea (OSA) compared with a placebo (look-alike substance that contains no active drug). The main question it aims to answer is: * If SGLT2i will reduce anatomic and physiologic traits, clinical measures of OSA and sleep deficiency in participants * If improvement in clinical measures are because of improvement in the anatomic and physiologic traits. Participants will be placed on either drug or placebo and get routine normal care for 6 months. At the start and end of the study, participants will undergo different clinical measurements to see if the drug makes the sleep apnea better.

This description comes directly from the study's public registry record.

Talk to the study team

Henry K Yaggi, M.D.  ·  203-785-4163  ·  henry.yaggi@yale.edu

Ian J Neeland, M.D.  ·  216-844-5965  ·  Ian.Neeland@UHhospitals.org

Always discuss trial participation with your own doctor first.

Locations (2)

Yale New Haven HealthNew Haven, Connecticut, United StatesRecruiting
University Hospitals Cleveland Medical CenterCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05612594