Condition: Epilepsy · Anomia · Temporal Lobe Epilepsy · Sponsor: Assistance Publique Hopitaux De Marseille
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis. The primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.
This description comes directly from the study's public registry record.
Veronique Sabadell · 0491385298 · veronique.sabadell@ap-hm.fr
Always discuss trial participation with your own doctor first.
| Service EFSN - Hôpital Pellegrin | Bordeaux, France | Recruiting |
| Service de Neurologie de l'Epilepsie - CHU Grenoble-Alpes | Grenoble, France | Recruiting |
| Département de Neurophysiologie Clinique - Hôpital Roger Salengro - CHU Lille | Lille, France | Recruiting |
| Hôpital Neurologique Pierre Wertheimer- Service de Neurologie Fonctionnelle et Epileptologie - Hospices Civils Lyon | Lyon, France | Not Yet Recruiting |
| Service Epilptologie et Rythmologie Cérébrale | Marseille, France | Recruiting |
| Service de Neurologie - Hôpital central -CHU Nancy | Nancy, France | Not Yet Recruiting |
| Département de Neurologie - Hôpital de la Pitié-Salpêtrière - APHP | Paris, France | Not Yet Recruiting |
| Service de Neurochirurgie -GHU Sainte-Anne | Paris, France | Not Yet Recruiting |
| Service de Neurologie - Fondation ophtalmologique de Rothschild - Fondation Rothschild | Paris, France | Recruiting |
| Service de Neurologie - CHU de Rennes | Rennes, France | Not Yet Recruiting |
| Service de Neurologie - Hôpitaux Universitaires, Hôpital de Hautepierre | Strasbourg, France | Recruiting |
| Explorations Neurophysiologiques, Pôle des Neurosciences - Hôpital Pierre Paul Riquet, Purpan | Toulouse, France | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT05609084