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Study identifier: NCT05606341 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Innate Immunity Stimulation Via TLR9 in Early AD

Condition: Mild Cognitive Impairment · Alzheimer Dementia  ·  Sponsor: NYU Langone Health

PhasePhase 1
Planned participants18
Who can joinAll sexes, 60 Years to 85 Years
Healthy volunteersNo

About this study

This single-center, double-blind, placebo-controlled study will recruit in total 39 participants with either Mild Cognitive Impairment due to Alzheimer's disease (MCI) or Mild Alzheimer's disease dementia (mild AD). There will be 3 Dose levels. An initial cohort of 13 subjects will be randomized to a Dose level 1 (0.1 mg/kg vs. placebo) lasting 8 weeks. An additional 13 subjects will be recruited and randomized into Dose level 2 (0.25 mg/kg vs. placebo) for 8 weeks and 13 subjects for the last Dose level 3 (0.5 mg/kg vs. placebo) for 8 weeks. The primary objective will be to assess safety and tolerability of CpG 1018.

This description comes directly from the study's public registry record.

Talk to the study team

Anaztasia Ulysse  ·  212-263-0771  ·  ADClinicalTrials@nyulangone.org

Dylan Nelson  ·  212-263-5845  ·  dylan.nelson@nyulangone.org

Always discuss trial participation with your own doctor first.

Locations (1)

NYU Langone HealthNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05606341